Medicine 3.0 Explained: Healthspan vs Lifespan and How to Age Slower

purpose of the talk was really to introduce you to one definition one outlook on what healthy aging longevity might look like all these terms mean something different to everybody so again my definitions may not align with yours but this is how I look at it and there are definitely many ways to interpret this so what's the current state of medicine and aging you know conventional medicine has done a lot but since the Advent of uh Advent of an biotics we haven't really done much to the mortality rate when you take out the infectious disease causes we're essentially dying at the same rate so why can't we fix lifestyle issues why can't we fix those things that kill us if they're not infectious so I'm not going to lie I don't know if anyone knows Peter AA here this is straight out of his book he talks about medicine 3.0 and the step up to 2.0 but what you see there on the Y AIS is your Health span versus your lifespan lifespan being the number the age you reach health is the quality of that life how well you are living so yes everybody starts at 100% And we deteriorate that's great what is medicine 2.0 what is the current state of conventional medicine goddess oh yeah a little bit longer time of not the best health so we want to maximize our time in good health Square the Curve or however you want to talk about it but be healthy until a later age and more functional so there is a difference between the young body and the old body I do do pediatric Sports Medicine adolescent sports medicine and I make the joke all every day I essentially do nothing their body fixes itself and I take all the credit I mean that's really my job it's easy all I do in clinic there is beat down the parents and build up the kids and teach them resiliency but the young body does have great repairative mechanisms we do lose that with aging there's nothing fancy about this or I'm not going to educate you anything the older body does have more damage have decreased repair capacities you know has problem clearing out and renewing cells so how do we work on that to maximize that Health span this has got a lot of stuff nobody can read it because it's a little bit smaller than I'd like but we're going to talk about the uh stem cell exhaustion alter intercellular communication what does that look like this is part of what aging is it is sort of an aging at the cellular level we really don't have a great answer to that that's okay um but what does it look like it's uh decreasing the capacity of our stem cells to regenerate we want regeneration every time you're here in the gym you're tearing muscles you have satellite cells moving into that muscle laying down new muscles cells those are stem cells that's great but as we age that capacity goes down separately the intracellular communication how the cells talk and say hey we've been damaged let's repair and let's repair stronger okay there is that capacity but it goes down as we get older and some of the things that feed that is mitochondrial uh dysfunction meaning the powerhouses of the cells just notun as well being more oxidative or causing more free radical damage and it inflammation that we're not quite turning off inflammation is a great thing it's how we heal our body but it needs to be turned off it can't be excessive and sort of the immune system and that mitochondria the powerhouses of the cell are the areas that I like to play around with so why is it important to age well you know it is about function you can say oh that's just a play on functional medicine but everybody here wants to be able to play with their grandkids or kids and do those things that are meaningful to us and lifegiving so how do we square that curve and you know this is where the functional medicine lens which is founded on lifestyle medicine how you approach movement it's great that you're members of the gym you're putting in your your time here that makes my job very easy easy nutrition Stress Management um relationships and sleep okay so we have all these factors that are working on tipping us towards frail and mo uh increased morbidity but what can we do to increase health we can take care of the lifestyle stuff lifestyle of diet exercise medicines potentially and then there are other Therapeutics the goal is to use lifestyle and not have to use a Therapeutics but that's what Med Matrix brings to the equation is that ability to intervene and help with the health span so what are some of the Practical approaches sorry you're going to have to deal with a little uh introduction to functional medicine for those of you who don't just transforming your health buffering stress through resiliency restoring through optimal sleep honoring the body through nutrition and centering the mind with movement so there's this fifth one called relationships and this is really you know one of the things isolation just magnifies all these life challenges so how do we biohack isolation or loneliness that's a whole another topic this is a wonderful representation of the interaction from many of the different lifestyle factors and if you could really blow this up you would see how exercise puts out its own chemicals or myocin or things released from the muscles from movement that are beneficial to our immune system system that are beneficial to bone health that help uh maximize nutrition and the utilization of your calories and there's all sorts of feed forwards and backwards here positive and negative so the focus being having a healthy lifestyle uh attaining the outcomes but that's the simple thing why why does everybody need medicine or need someone to help them with their health because it's sometimes not as easy as it sounds there are hurdles why are you not getting the gain on your or the return on your investment of being here in the gyms sometimes that is an issue and that's what we work on so why lifestyle medicine I just read this to you compared to individuals having zero to one healthy lifestyle Behavior if you have five to six healthy lifestyle behaviors you really take down your risk 70% lower prevalence of cardiovascular disease still the number one killer of all males and females and systematically improving lifestyle is improving your healthspan and your lifespan so lifestyle medicine is one of the more powerful medicines in your toolkit we like to see it say exercises medicine and sports medicine and that's great I will Adit my bias I do not enjoy working with clients as much if they don't have a movement practice because it really is something that moves the needle okay even more more so than nutrition and we can talk about that there are people that have sensitivities and that have to be respected but definitely not dogmatic about it so what are some of these things that we can measure how can how can your providers help you you know what is a measure of healthspan lifespan is a number but healthspan what are some of the things you should be focused on and the functional parameters that you see listed on the right side V2 strength grip strength the ability to uh know where you're at in space or appropriate setion again I throw around the fancy terms that fake you out make you think I'm smart but you know things like that how well can you get up and go these are all functional parameters and something that are easy and expensive functional medicine does bring some other testing to see how your cells are handling things maybe you're feeding your body well but your mitochondria the things that generate energy from from the uh fats carbs and um protein are just not working as well and so sometimes you have to go into the molecular markers whether it be the epigenetic markers or how your cells are utilizing energy so they're easy things why does this matter because yes we are aging okay that is going to happen no matter what people like to talk about steps is there really a benefit from being active absolutely this is a hazard risk of death and the lower your number of steps the greater your hazard ratio is and as you get more steps especially if you're over 60 there doesn't seem to be a J curve yeah under 60 maybe there might be if you get a little higher but more steps more movement equals more Health what about V2 Max you know you may know the studies that say um and there'll be another slide after this one that the higher your V2 Max is your ability to use oxygen to make energy at the cellular level or consume oxygen at the cellular level and make energy um goes down with age well if that's a fact if your V2 Max is going to go down with age is what you're seeing here in every one of these people if you want to be able to walk on flat Grand at three at 20 minutes A Mile by the time you're 75 you have to have a certain V2 Max okay so I actually I how many people know Peter AA I've heard the term or know the book okay so I don't I'm not a petera puppet but he is a wonderful voice in the area of Health span and Longevity and I do like a term he stole from someone else and that is back casting you have to figure out where you want to be in your her his term terminal decade what do you want to be able to do in the decade before you pass away what it what does that take what kind of V2 does that tag take and then you have to backtrack so in short you want to have a very good V2 because you're only going to lose it so these are some fancy bio statistics but the this is compared to the Elite V2 and the mortality risk the risk only goes up the more unfit you are there is not a J curve or getting worse compared to Elite so even high the top 5% of BO2 has a slightly increased Hazard ratio of death compared to the elite elite and it just goes up now i' like to at least leave with some hope and yes those that are doing nothing they have the greatest gains to make and those of you that are spending a lot of time in the gym you're sort of like is this really valuable there's always value to be made and gaining muscle gaining BO2 or aerobic capacity um it does go up but the gains are going to be greater for those coming from a lower level of Fitness you know and everyone wants to talk about smoking kidney disease diabetes they are very significant increasers horrible English there sorry they sign ific anly decrease our health span and our lifespan but when you look at their Hazard ratios of having them and not having them look at the multiplier of what being physically fit does for you way over there so again mid adult life it's never too late to start yes we get a peak in early life it's great get that Peak as high as you can but you can slow the rate of descent by putting in that work working on muscle Etc so this this is just showing incidents of dementia versus your hand grip strength goes down why does anyone know why hand grip strength is a good measure what's the measure of if your the ability to grip something and hold it tightly is how well your blood vessels are reactive how reactive how healthy your blood vessels are so just squeezing things if you did isometric work or did wall sits you're going to do wonders for your blood vessel health and high blood pressure or anything if you say what's the best exercise for my high blood pressure wall hits you know isometrics or go ahead and carry the kettle bells back and forth so what's the low hanging fruit one I had didn't even put on here and I thought about it this morning as I was coming in water okay staying well hydrated but also using water as a displacement for the things that are calorically dense I.E caloric Beverages and then the other one when we're talking about body composition unfortunately and I'm not a tea totaler alcohol um but protein very protein forward obviously I'm muscle Centric forward you wouldn't know that by looking at me but um protein about a gram per pound of weight okay that's a lot and hard to do that without supplementation but if you really are going to get up in that area taking a quarter of a pound of your weight putting it in the middle of your feeding window and putting the other 37.5% at the when you first wake up and close to bed without interfering with sleep fiber fiber fiber we'll come back to why that's important vitamin D for immune and metabolic function and the omega3 is for again for the immune health so what are some of the advanced approaches what is med Matrix bringing to the table you're already in the gym you're doing the things that I my big ask my big ask is to move your body to use your muscles um but this is where we talk about what is aging some would say just metabolic dysfunction or that inability to work efficiently okay and the mitochondria I keep throwing that around the PowerHouse of every cell really concentrated in your nerves where's the big source of your nerves your brain so cognitive Health um your immune system we obviously got a little uh refresher on that with Co about how important our immune system is and then our muscles in every cell of our body so you can decrease metabolic dysfunction what feeds metabolic dysfunction inflammation okay where can inflammation come from everywhere and I already said that inflammation is not necessarily bad where body our body heals through inflammation we just have to turn it off how do we turn it off how do we avoid sort of this chronic low-level inflammation or that inflam aging so why is fiber so good okay the big talk now is around semi glutide and glp1 well that's what fiber does fiber and resistant starches get down to our colon 10 hours after we ingest them they get fermented into things that uh trigger glp One release and that is why fiber can decrease satiety can give you all these other benefits of decreasing the inflammation of insulin now this for those of you that are very very astute you can see that glp1 will induce insulin secretion I'm saying insulin is inflammatory producing and this kind of gets cut both ways I'll admit speaking with a little Fork a ton here but generally fiber is going to be doing that how many people have heard of OIC or semi glutide and things like that that's essentially taking a dose of fiber and turning it on constantly so we are using conventional medicine we are using things like that to get the benefit of fiber all the time some people do not tolerate fiber it is great great great unless you get a bloated belly and you feel absolutely miserable from it can you do it with fiber yes absolutely anything that's fermentable resistant starches there is a reason your grandmother may have told you to eat your potatoes cold when they get cold after being cooked they produce more resistance starch starch that feeds your microbiome your gut bacteria and gets fermented by them to give you the benefit of a glp1 Agonist or something like semi glutide for those who don't know this is a protein it's amino acids it's a peptide so again I've threw out a lot of things there amino acids go together to make peptides uh protein is a long peptide and this is where conventional medicine we said anything on 50 amino acids was meaningless well of course we don't know everything it took us few decades to figure out hey these really short uh proteins that are only a few peptides 15 50 whatever they actually do a lot in our body and that's what semi glutide is is a glp1 Agonist it is working on satiety it's taking that food uh food uh craving down a notch but also doing other things that are beneficial to the health and you know it was originally developed as a diabetes medicine so helping with insulin sensitivity helping with heart function helping with vascular function all these things that are contributing to our shortened and impaired Health span so other things that we offer besides just you know good functional medicine can you do it through food nutrition Stress Management sleep and relationships hormone replacement therapies yes things change and a lot of people want to say it's always my thyroid if I have body composition issues it's always my thyroid I really wish I had a penny for every time I heard that it rarely is a thyroid sometimes it is okay I'm not saying it never is but it's not nearly as much as people think and sex hormones with menopausal changes or getting age older all those things are great the thing about the hormone system system is it's a self-regulating system if you take care of it it tends to uh self-regulate fairly well so if you're not dealing with the adrenals the thyroid and the sex hormones are going to be abnormal if you're not dealing with the thyroid the sex hormones can be abnormal so there's really you need to start at the top what stresses out the adrenals the most inadequate recovery excessive Sport and exercise or movement or impaired sleep so while everybody wants to say body composition is insulin insulin insulin thanks to a good book by Dr fun if anyone wants to read it the Obesity code love it because he mostly slams doctors for the first five chapters about how poor we've been with dealing with obesity um but he's all about insulin and it's really not recognizing the cortisol effect um other uh options other things available at Med Matrix are regenerative IM immune modulating therapy whether it be IV infusions NAD or glutathione glutathion actually our Master antioxidant and I talked about inflammation Everyone likes to think of vitamin C and vitamin E is our Master antioxidant but glutathione is we have peptide therapies where one semi glutide is a peptide therapy but then also things such as um other peptides that'll work on the growth hormone access you're here working on a gym and you're not quite getting the growth hormone response because we're getting a little older well we can kind of push on that system and let you get the uh return on your investment versus mesal stem cells and exomes okay we said stem cells are still in our body no matter what our age is they just aren't as reactive so we can use stem cells we can use their products to sort of send the signals cool off inflammation balance the immune system and let's grow let's grow in a positive way so I don't know has anybody heard of exosomes so a few people have heard of it and most often you're going to hear an orthopedic cons conditions okay so there are many different things we do for joint pain again another area we failing people just saying oh you have to deal with your joint pain and your ostearthritis there's actually things that can be done starting with education functional man lifestyle medicine but exomes are sort of that trigger to kind of turn the course you know how do you tell someone to be more active when being more active causes pain we kind of have to help some sometime we have to help and not just blame the patient so exomes are so much On The Fringe and very much of interest to patients and and the science Community we're learning things every day and there is not a hard science I'm not going to sit here and tell you I have randomized controlled trials to say exomes help but I got in the functional medicine because I was like conventional medicine is not helping my patients who's helping my patients that say that conventional medicine said you've got nothing for me and functional medicine has some answers for majority of patients when it came to the sports medicine aspect it's those working in regenerative medicine those that are providing the exosomes that are turning the turning turning things around uh in regards to inflammation and function okay so there's never a Magic Bullet but this has gone beyond Orthopedics and it's being applied to all conditions of aging and you may say well why why does it work what's the root cause so I haven't even thrown that out once how that's a first get 30 minutes in and not say root cause but what's the root cause of the inflammation and um you know it can be mechanics it can be all sorts of things but exosomes do work on those inflammatory Pathways as cin or um or map kyes Etc so so yes it's not just Orthopedic conditions it is age related conditions and am I going to sit here and tell you it reverses everything or re takes your life back 10 years no but if you are not getting the benefit from all the work you're putting into lifestyle you know we have some solutions for you so and I'll