Fibromyalgia and Chronic Pain: What Drives It, What to Test, Where Functional Medicine Starts

Colin Renaud, PA-C, Dr. Sasha Rose, ND, LAc, MSOM49:12Pain & RecoverySeptember 11, 2026
Listen onYouTube

Episode Summary

A fibromyalgia case opens the episode: five years of widespread pain, plenty of hours of sleep that were not refreshing, a full specialist workup, and normal results. Colin Renaud and Dr. Sasha Rose define fibromyalgia, explain why it is not a diagnosis of exclusion, and describe central sensitization, the change in how the nervous system processes signals that makes light touch genuinely hurt. Both are clear that the conventional workup matters and should never be skipped, because hypothyroidism, iron deficiency, low vitamin D or B12, inflammatory arthritis, polymyalgia rheumatica, sleep apnea, celiac disease and medication side effects all have to be ruled out before anyone lands on the diagnosis. From there they cover what a functional medicine evaluation adds once the label is in hand, including sleep, nutrient status, hormones and nervous system regulation, and why aggressive online detoxes, elimination diets and intense exercise plans tend to backfire on a system that is already overreacting. A live audience Q&A takes questions on overactive nerves, whether it runs in families, acupuncture and why symptoms can feel worse over the years, and the episode ends on one closing takeaway: normal results are not the same as nothing happening.

Key Topics

  1. 1

    What fibromyalgia actually is

  2. 2

    Central sensitization and pain threshold

  3. 3

    Why fibromyalgia is not a diagnosis of exclusion

  4. 4

    How long a diagnosis takes and why

  5. 5

    Women dismissed as anxious or stressed

  6. 6

    Conditions that must be ruled out first

  7. 7

    Nervous system triggers and flares

  8. 8

    Overlap with hypermobility, POTS and mast cell activation

  9. 9

    Why aggressive online protocols backfire

  10. 10

    Sleep, nutrients and hormones in chronic pain

Quotable Moments

The biggest takeaway would be that your pain is real. You're not making it up. It has a mechanism.

For somebody dealing with fibromyalgia, that same even light touch, light pressure really does hurt

If you're having a GI problem, if you're having a heart problem, if you're having a neurological problem, we always have to rule out the bad stuff first.

And this is why two people can have the same fibromyalgia diagnosis but need completely different treatment plans.

there's a real difference between a condition that nobody can really explain at all and a condition that nobody has actually properly looked for and evaluated.

Treatments Mentioned

Conventional rheumatology or pain specialist workup to rule inflammatory and autoimmune conditions in or outThyroid testing for hypothyroidismIron deficiency and anemia screeningVitamin D and B12 testing, and correcting low levelsSleep apnea evaluation and sleep regulationHormone evaluation, including low estrogen in women and low testosterone in menReview of current medications, including statins as a cause of muscle painAcupuncture from a practitioner who knows fibromyalgia and this kind of pain sensitivity

Pain & Recovery FAQ

Dr. Rose says it's real, and that it's not a diagnosis of exclusion the way irritable bowel syndrome is, even though it often gets treated that way. What is recognized underneath it is central sensitization along with a dysregulation in the neurotransmitter system, so the nervous system processes signals differently and the pain threshold is different. Light touch or light pressure that another person would barely notice genuinely hurts, and she is clear that nobody is making that up.

No. Dr. Rose says normal results can be really good news, because they mean there is nothing dangerous going on, and that is not the same as nothing happening. There is a huge gap between those two things, and she says that is often when those people come to them. Normal results don't mean the pain isn't real, and they don't mean it's all in your head or just stress.

Dr. Rose names hypothyroidism, iron deficiency including anemia, severe vitamin D or B12 deficiency, inflammatory arthritis, other autoimmune conditions affecting connective tissue and muscle, polymyalgia rheumatica, untreated sleep apnea, celiac disease, side effects of certain medications such as statin-related muscle problems, and depression. She also says it is possible to have several of these at once, fibromyalgia included, so finding one does not close the file on the rest. Colin added that ruling out the serious causes always comes first, whatever the complaint is.

Colin points to several things stacking up. There's no confirmatory blood test, the diagnosis runs off clinical criteria, the symptoms overlap with anxiety and depression, and appointments are short. He also points to the referral pattern, since the share of fibromyalgia patients who are women is much higher in referral clinics than in unselected patient samples, which he said tells us something uncomfortable about who gets referred and who is ultimately believed. He called it a systems problem.

Dr. Rose is a licensed acupuncturist and her answer was measured. Acupuncture can help some people some of the time, and no single modality helps every person every time. She thinks it is worth trying, as long as you find an acupuncturist who understands the nuances of fibromyalgia and this kind of pain sensitivity, because the points chosen and even the needles used should be personalized. If it works for you, it can be a good part of an overall treatment plan.

Colin says his understanding is that fibromyalgia is not a progressive disease and does not necessarily cause physical damage to the body, but symptoms can feel worse over time because of aggravating factors: a stressor, nervous system dysregulation, years of poor sleep, and reduced physical activity. Dr. Rose added that hormonal changes with age affect it too, and that pain limiting movement and exercise can become a vicious cycle that keeps inflammation high. Colin was explicit that this is not the patient's fault. People don't feel well, and reduced stamina makes things worse.

Related Service

Learn More

Advanced Lab Testing

Your PCP runs 10 markers. We test 80+. Full thyroid, fasting insulin, hormones, inflammatory markers, and InBody scan in South Portland, ME. 60-min review. 4.8 stars. $100 off.

Free practice guide and $100 voucher for functional medicine consultation at Med Matrix

Your Health, Your Terms

Start Feeling Like Yourself Again

Get your free practice guide and a $100 voucher toward your first visit. No commitment, no pressure.