Hormone Replacement Therapy
Hormone Replacement Therapy in Maine and New Hampshire
Hormone decline shows up for women as fatigue, weight gain, mood shifts, hot flashes, and brain fog. Med Matrix runs a comprehensive 80-biomarker panel, identifies what is out of range, and builds a bioidentical HRT protocol around your actual results.
What Is Bioidentical Hormone Replacement Therapy?
Bioidentical hormone replacement therapy (BHRT) uses hormones that are molecularly identical to what the human body produces naturally. At Med Matrix, HRT for women addresses estradiol, progesterone, testosterone, DHEA, and thyroid hormones based on comprehensive lab testing, not symptom assessment alone. The 80+ biomarker panel checks sex hormones alongside thyroid, cortisol, metabolic markers, and inflammation to capture the full hormonal picture before any prescription is written. Providers recheck labs at every follow-up visit to track hormone levels, adjust doses precisely, and monitor for changes in metabolic or inflammatory markers over time.
Looking for testosterone replacement therapy? Visit our TRT page.
What's Included in the Med Matrix BHRT Program
Every HRT patient gets a full workup and a protocol built from her labs, not a one-size-fits-all prescription. Here is what your program covers.
80+ Biomarker Baseline Panel
Estradiol, progesterone, testosterone, DHEA, full thyroid, cortisol, fasting insulin, and inflammation markers measured before anything is prescribed.
InBody 770 Body Composition Scan
Muscle mass, fat mass, and visceral fat measured at onboarding and follow-ups, so midsection weight changes are tracked with data, not guesswork.
One-Hour Provider Consultation
A full hour walking through every result, followed by a personalized BHRT protocol built around your labs, symptoms, and stage of the transition.
Bioidentical Hormones
Estradiol, progesterone, and testosterone in bioidentical forms, dosed to your levels and sourced from licensed pharmacies.
Labs Rechecked at Follow-Ups
Follow-up panels track your hormone levels so doses are adjusted on data as your body responds. Follow-up visits are $275.
Direct Care Team Access
Questions between visits go to your care team, not a call center. Protocol changes happen when your labs and symptoms call for them.
Full onboarding runs approximately $1,200 to $1,500 all-in, with ongoing therapy typically $70 to $200 per month. New patients receive a $100 voucher toward their first visit. HSA and FSA accepted.
LOCATIONS WE SERVE
Find HRT Near You
Greater Portland & Surrounding Suburbs
Casco Bay & Coastal Communities
Central Maine
Southern Maine Coast
Who Leads HRT at Med Matrix
These providers build and monitor every women's hormone protocol personally.
Real HRT Patient Stories
Hear from women who rebalanced their hormones at Med Matrix.

Joy
Joy struggled through 6 years of menopause with no sleep, hot flashes, irritability, and anxiety while her prior doctor never checked her labs and told her to work out more. Her husband gave her a Med Matrix gift card for Christmas. Working with Colin and Jamie via telehealth (she lives 3 hours north), she switched to compounded hormone creams and targeted supplements, and is now sleeping through the night.
“I sleep. That's the biggest thing. I actually sleep.”

Cat
Cat, a type 1 diabetic and former fitness instructor, spent three years suffering through severe menopausal symptoms while conventional doctors kept increasing her estrogen and dismissing her concerns. Blood testing at Med Matrix revealed she actually needed progesterone and testosterone in addition to estrogen, plus had significant inflammation. After roughly six months on a balanced hormone protocol and targeted supplements, her weight stabilized, sleep improved, anxiety resolved, moods balanced, and she feels like herself again. Med Matrix also resolved a gut issue in two months with two supplements, where her primary care had been unable to diagnose it after months of testing.
“I kept going back to my insurance-paying general PCP and OB, they just kept giving me more and more estrogen, which seemed to actually make the symptoms a whole lot worse. I was feeling really, really terrible.”
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FAQ
HRT Questions
Common questions about hormone replacement therapy at Med Matrix.
Hormone replacement therapy restores hormones that have declined due to age, stress, or underlying health conditions. At Med Matrix, we run an 80-biomarker blood panel to measure your estrogen, progesterone, testosterone, thyroid, cortisol, and other key markers before building a personalized protocol around your actual lab results.
Bioidentical hormones are structurally identical to the hormones your body produces naturally. Conventional synthetic hormones use modified molecules that behave differently in your body. At Med Matrix, we use bioidentical options whenever clinically appropriate and tailor dosing to your labs, not a one-size-fits-all prescription.
HRT is for women experiencing symptoms of hormone imbalance: fatigue, mood changes, weight gain, poor sleep, low libido, brain fog, hot flashes, or irregular cycles. These symptoms can appear in your 30s, 40s, 50s, or beyond. We test first and treat based on your data, not age alone.
There is no single right age. Many women benefit from starting HRT during perimenopause, when estrogen and progesterone begin to fluctuate, rather than waiting for menopause itself. The deciding factor is your labs and symptoms together. Our providers run an 80-biomarker panel first, then walk you through whether HRT makes sense now or whether monitoring is the better next step.
Full onboarding runs approximately $1,200 to $1,500 all-in, covering your 80-biomarker lab panel, InBody 770 body composition scan, provider prep time, and a full one-hour provider consultation. Ongoing HRT therapy typically runs $70 to $200 per month depending on your protocol. New patients receive a $100 voucher toward their first visit. We accept HSA and FSA accounts.
BHRT stands for bioidentical hormone replacement therapy. Bioidentical hormones are molecularly identical to the hormones a woman's body produces naturally, unlike older synthetic versions. At Med Matrix, BHRT protocols are dosed to your labs and rechecked at every follow-up visit, so your levels are restored gradually and precisely.
Common perimenopause signs include irregular or heavier cycles, hot flashes, night sweats, waking between 2am and 4am, new anxiety or irritability, brain fog, and weight gain around the midsection. Perimenopause can start 8 to 10 years before your final period, which is why symptoms often appear in your late 30s and 40s. Lab testing shows where you actually are in the transition.
Most women notice improvements in sleep and hot flashes within 2 to 4 weeks. Mood, energy, and mental clarity typically improve over the first 2 to 3 months as levels stabilize. Your provider rechecks labs at follow-up visits and adjusts dosing based on your results and your symptoms together, so progress is tracked with data.
For most women, bioidentical HRT is safe when it is prescribed from comprehensive lab work and monitored by a licensed provider. Safety comes from the process: testing 80+ biomarkers first, dosing to your individual levels, and rechecking labs at every follow-up. Your provider reviews your personal and family history to confirm HRT is appropriate before anything is prescribed.
Yes. Med Matrix serves women across Maine and New Hampshire from our South Portland clinic, including patients from Portsmouth, Dover, Rochester, and the Seacoast area. Many patients drive 30 to 60 minutes for a full hormone panel and provider-led BHRT care they cannot find locally.

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